Synchronous adrenocortical carcinoma and rhabdomyosarcoma in a child with p53 Overexpression on immunostaining

We describe a child with synchronous malignancies. The patient presented with adrenocortical tumor (ACT) of left adrenal gland and rhabdomyosarcoma (RMS) on the left thigh and successfully treated with surgery and chemotherapy. The occurrence of these two cancers in the same child met “Chompret crit...

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Bibliographic Details
Published inPediatric hematology oncology journal Vol. 5; no. 3; pp. 119 - 122
Main Authors Mohapatra, Sonali, Mahalik, Santosh Kumar, Sable, Mukund Namdev, Das, Kanishka
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2020
Elsevier
Subjects
Adrenocortical carcinoma
Children
p53 mutation
Rhabdomyosarcoma
Synchronous tumour
Synchronous tumour
p53 mutation
Children
Adrenocortical carcinoma
Rhabdomyosarcoma
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Summary:We describe a child with synchronous malignancies. The patient presented with adrenocortical tumor (ACT) of left adrenal gland and rhabdomyosarcoma (RMS) on the left thigh and successfully treated with surgery and chemotherapy. The occurrence of these two cancers in the same child met “Chompret criteria” for Li Fraumeni syndrome (LFS), although there was no family history of cancer. Overexpression of p53 was detected by immunostaining but unfortunately, we were unable to screen for TP53 mutations. The unique presentation of our patient is described, and the significance of finding two simultaneous solid tumors in a child, with the importance of counseling for cancer predisposition syndromes is discussed.
ISSN:2468-1245
2468-1245
DOI:10.1016/j.phoj.2020.06.010