Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats

3β, hydroxy-lup-20(29)-en-28-oic acid (Betulinic acid), a pentacyclic lupane-type triterpene has diverse pharmacological functions both in vitro and in vivo. The present study focuses its protective effect on polycyclic aromatic hydrocarbon (7,12- Dimethylbenz(a)anthracene or DMBA) induced alteratio...

Full description

Saved in:
Bibliographic Details
Published inJournal of xenobiotics Vol. 7; no. 1
Main Authors Kaur, Pardeep, Kaur, Rajbir, Arora, Rohit, Arora, Saroj
Format Journal Article
LanguageEnglish
Published MDPI AG 28.04.2017
Subjects
3β, hydroxy-lup-20-en-28-oic acid
7,12-Dimethylbenz(a)anthracene
extrahepatic organs
oxidative stress
polycyclic aromatic hydrocarbon
xenobiotics
Online AccessGet full text

Cover

More Information
Summary:3β, hydroxy-lup-20(29)-en-28-oic acid (Betulinic acid), a pentacyclic lupane-type triterpene has diverse pharmacological functions both in vitro and in vivo. The present study focuses its protective effect on polycyclic aromatic hydrocarbon (7,12- Dimethylbenz(a)anthracene or DMBA) induced alterations in membrane bound ATPases, detoxification enzymes and antioxidant enzymes in stomach and lungs of female Sprague Dawley rats. Healthy female Sprague Dawley rats were randomly assorted into six groups and the treatments were given orally for 7 weeks on alternate days. It was observed that betulinic acid facilitated the downregulation of elevated membrane bound ATPases (Na+/K+- ATPase, Ca2+-ATPase and Mg2+-ATPase) in DMBA administered rats. Likewise, the detoxification enzymes as well as antioxidant enzymes were modulated to normalcy in rats. Overall, betulinic acid was seen to be effective modulator of DMBA induced alterations in biochemical parameters.
ISSN:2039-4705
2039-4713
DOI:10.4081/xeno.2017.6475