Targeting BCL-2 overexpression in various human malignancies through NF-κB inhibition by the proteasome inhibitor bortezomib

• Published in: Cancer chemotherapy and pharmacology Vol. 56; no. 1; pp. 46 - 54
• Main Authors: FAHY, Bridget N, SCHLIEMAN, Michael G, MORTENSON, Melinda M, VIRUDACHALAM, Subbulakshmi, BOLD, Richard J
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.07.2005
• Subjects: Antineoplastic agents; Biological and medical sciences; Medical sciences; Pharmacology. Drug treatments; Antineoplastic agent; Multicatalytic endopeptidase complex; Targeting; Extracellular signal-regulated protein kinase; Gene overexpression; Malignancy; BCL-2; NF-κB; Target; MEK/ERK; Transcription factor NFκB; Inhibition; Protooncogene; p38MAPK; Human; Bortezomib; Enzyme; Transferases; Mitogen-activated protein kinase; Malignant tumor; PI-3 Kinase; 1-Phosphatidylinositol 3-kinase; Peptidases; C-Onc gene; Hydrolases; Inhibitor
• ISSN: 0344-5704; 1432-0843
• DOI: 10.1007/s00280-004-0944-5