Cell growth on electrospun nanofiber mats from polyacrylonitrile (PAN) blends

Nanofiber mats can be produced by electrospinning from diverse polymers and polymer blends as well as with embedded ceramics, metals, etc. The large surface-to-volume ratio makes such nanofiber mats a well-suited substrate for tissue engineering and other cell growth experiments. Cell growth, howeve...

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Bibliographic Details
Published inAIMS bioengineering Vol. 7; no. 1; pp. 43 - 54
Main Authors Wehlage, Daria, Blattner, Hannah, Mamun, Al, Kutzli, Ines, Diestelhorst, Elise, Rattenholl, Anke, Gudermann, Frank, Lütkemeyer, Dirk, Ehrmann, Andrea
Format Journal Article
LanguageEnglish
Published AIMS Press 01.01.2020
Subjects
adherent cells
autoclaving
cell growth
cho cells
dmso
electrospinning
nanofiber mat
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Summary:Nanofiber mats can be produced by electrospinning from diverse polymers and polymer blends as well as with embedded ceramics, metals, etc. The large surface-to-volume ratio makes such nanofiber mats a well-suited substrate for tissue engineering and other cell growth experiments. Cell growth, however, is not only influenced by the substrate morphology, but also by the sterilization process applied before the experiment as well as by the chemical composition of the fibers. A former study showed that cell growth and adhesion are supported by polyacrylonitrile/gelatin nanofiber mats, while both factors are strongly reduced on pure polyacrylonitrile (PAN) nanofibers. Here we report on the influence of different PAN blends on cell growth and adhesion. Our study shows that adding ZnO to the PAN spinning solution impedes cell growth, while addition of maltodextrin/pea protein or casein/gelatin supports cell growth and adhesion.
ISSN:2375-1495
2375-1487
2375-1495
DOI:10.3934/bioeng.2020004