InCl3 mediated one-pot synthesis of indol-3-yl pyridine and 2,2 '-bipyridine derivatives through multi-component reaction

A simple protocol for the efficient preparation of 2-(1H-Indol-3-yl)-6-methoxy-4-aryl pyridine-3,5-dicarbonitrile and 6-methoxy-4-aryl-2,2'-bipyridine-5-carbonitrile derivatives has been achieved through one-pot multi-component reaction under reflux condition. Particularly valuable features of...

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Bibliographic Details
Published inTetrahedron Vol. 65; no. 36; pp. 7620 - 7629
Main Authors Thirumurugan, Prakasam, Perumal, Paramasivan T.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 05.09.2009
Subjects
Chemistry
Chemistry, Organic
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Organic chemistry
Physical Sciences
Preparations and properties
Science & Technology
SUBSTITUTED 2-AMINOPYRIDINES
POLYMERS
ANALOGS
COMPLEXES
AGENTS
INDOLE ALKALOIDS
FACILE
EFFICIENT
One pot reaction
Nitrile
Multicomponent reaction
Nitrogen heterocycle
Bipyridines
Aromatic compound
Indium III Chlorides
Indole derivatives
Chemical synthesis
Dinitrile
Pyridine derivatives
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Summary:A simple protocol for the efficient preparation of 2-(1H-Indol-3-yl)-6-methoxy-4-aryl pyridine-3,5-dicarbonitrile and 6-methoxy-4-aryl-2,2'-bipyridine-5-carbonitrile derivatives has been achieved through one-pot multi-component reaction under reflux condition. Particularly valuable features of this method include high yields of products in short reaction time and broad substrate scope. It is an efficient and promising synthetic strategy to build indol-3-yl pyridine and 2,2'-bipyridine skeletons. (C) 2009 Elsevier Ltd. All rights reserved
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2009.06.097