Androgen insensitivity in forty-nine patients: classification based on clinical and androgen receptor phenotypes

Androgen receptor binding was studied in genital skin fibroblasts from 49 patients with androgen insensitivity syndrome (AIS) classified as complete (CAIS) or partial (PAIS) based on the clinical phenotype. The majority (64%) of CAIS and a minority (7%) of PAIS patients were receptor negative. Only...

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Bibliographic Details
Published inHormone research Vol. 28; no. 1; p. 25
Main Authors Hughes, I A, Evans, B A
Format Journal Article
LanguageEnglish
Published Switzerland 1987
Subjects
Androgen-Insensitivity Syndrome - classification
Androgen-Insensitivity Syndrome - genetics
Androgen-Insensitivity Syndrome - metabolism
Fibroblasts - metabolism
Humans
Male
Phenotype
Receptors, Androgen - genetics
Receptors, Androgen - metabolism
Skin - metabolism
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Summary:Androgen receptor binding was studied in genital skin fibroblasts from 49 patients with androgen insensitivity syndrome (AIS) classified as complete (CAIS) or partial (PAIS) based on the clinical phenotype. The majority (64%) of CAIS and a minority (7%) of PAIS patients were receptor negative. Only 3 receptor-positive AIS cell strains of 30 studied failed to show an increase in specific receptor binding after prolonged androgen exposure in vitro. The gene coding for the androgen receptor in such patients appears intact.
ISSN:0301-0163
DOI:10.1159/000180921