Investigations on the synthesis and pharmacological properties of N-substituted derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones

• Published in: Farmaco (Società chimica italiana : 1989) Vol. 60; no. 1; pp. 53 - 59
• Main Authors: Śladowska, Helena, Filipek, Barbara, Szkatuła, Dominika, Sapa, Jacek, Bednarski, Marek, Ciołkowska, Marta
• Format: Journal Article
• Language: English
• Published: France Elsevier SAS 2005
• Subjects: 3,4-Pyridinedicarboximide derivatives; 4-Alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3 (2H)-diones; Analgesia; Analgesic and sedative activities; Analgesics - chemical synthesis; Analgesics - chemistry; Analgesics - pharmacology; Animals; Lethal Dose 50; Male; Mice; Motor Activity - drug effects; Pyrroles - chemical synthesis; Pyrroles - chemistry; Pyrroles - pharmacology; Structure-Activity Relationship; Synthesis; Synthesis; 4-Alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3 (2H)-diones; Analgesic and sedative activities; 3,4-Pyridinedicarboximide derivatives
• ISSN: 0014-827X; 1879-0569
• DOI: 10.1016/j.farmac.2004.08.011

Synthesis of N-substituted derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones ( 10– 14, 18– 21) is described. In the “writhing syndrome” test all compounds studied exhibited potent analgesic activity which was superior than that of acetylsalicylic acid. In the “hot plate” test imides 10, 12, 13, 18– 20 acted also stronger than aspirin. Furthermore all compounds tested significantly suppressed the spontaneous locomotor activity of mice and prolonged barbiturate sleep of these animals.