Simultaneous Spectrophotometric Determination of Salbutamol and Bromhexine in Tablets

Typical anti-mucolytic drugs called salbutamol hydrochloride and bromhexine sulfate encountered in tablets were determined simultaneously either by using linear regression at zero-crossing wavelengths of the first derivation of UV-spectra or by application of multiple linear partial least squares re...

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Published inFarmaco (Società chimica italiana : 1989) Vol. 60; no. 3; pp. 249 - 254
Main Authors Habib, I.H.I., Hassouna, M.E.M., Zaki, G.A.
Format Journal Article
LanguageEnglish
Published France Elsevier SAS 01.03.2005
Subjects
Albuterol - analysis
Algorithms
Antitussive Agents - analysis
Bromhexine
Bromhexine - analysis
Chromatography, High Pressure Liquid
First derivative
Pharmaceutical Preparations - analysis
PLS
Regression Analysis
Salbutamol
Spectrophotometry, Ultraviolet - methods
Tablets - chemistry
UV-spectrophotometry
Bromhexine
Salbutamol
First derivative
PLS
UV-spectrophotometry
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Summary:Typical anti-mucolytic drugs called salbutamol hydrochloride and bromhexine sulfate encountered in tablets were determined simultaneously either by using linear regression at zero-crossing wavelengths of the first derivation of UV-spectra or by application of multiple linear partial least squares regression method. The results obtained by the two proposed mathematical methods were compared with those obtained by the HPLC technique.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0014-827X
1879-0569
DOI:10.1016/j.farmac.2004.11.007