Chiroptical properties of fluorescamine condensation compounds with α-amino acids in situ

Fluorescamine reacts efficiently with primary amino acids to form pyrrolinone-type chromophores. A simple test tube procedure is described which allows in situ determination of absolute configuration of α-amino acids based on the chiroptical properties of these chromophoric derivatives.

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 69; no. 1; pp. 206 - 211
Main Authors Toome, V., Wegrzynski, B., Reymond, G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 08.03.1976
Subjects
Amino Acids
Binding Sites
Circular Dichroism
Fluorescamine
Molecular Conformation
Pyrroles
Spectrophotometry, Ultraviolet
Spiro Compounds
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Summary:Fluorescamine reacts efficiently with primary amino acids to form pyrrolinone-type chromophores. A simple test tube procedure is described which allows in situ determination of absolute configuration of α-amino acids based on the chiroptical properties of these chromophoric derivatives.
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ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(76)80293-8