Coumarins from Musineon divaricatum

• Published in: Phytochemistry (Oxford) Vol. 24; no. 4; pp. 805 - 813
• Main Authors: Swager, T.M, Cardellina, J.H. II
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 1985; Elsevier
• Subjects: Analytical, structural and metabolic biochemistry; Apiaceae; Aromatic and heterocyclic compounds; Biological and medical sciences; chemical constituents of plants; coumarins; Fundamental and applied biological sciences. Psychology; Heterocyclic compounds, pigments; HPLC; identification; isolation; Musineon divaricatum; Other biological molecules; Umbelliferae; Musineon divaricatum; isolation; identification; Umbelliferae; coumarins; HPLC; Vegetals; Molecular structure; Dicotyledones; Angiospermae; Spermatophyta; Coumarin
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(00)84899-2

A chemical investigation of Musineon divaricatum has resulted in the isolation of 19 coumarins, five of which are novel compounds; 18 are khellactone derivatives. The coumarins were isolated from the crude extracts by a combination of adsorption chromatography, gel permeation and HPLC; the more successful HPLC separations utilized a nitrile bonded phase column. The structures were determined by 1H NMR and mass spectral studies and by comparisons with literature data. The relative configuration for the entire series was secured from 1H NMR data, while the absolute configuration could be assigned with any certainty only in the cases of two of the compounds.