The analytical control of the composition of creams

The analysis without prior sample clean-up of promethazine hydrochloride or clioquinol in commercially available creams has been investigated using UV-spectrophotometry and titrimetric methods. The results were compared with those obtained by GLC and HPLC. Although in some cases the active drug coul...

Full description

Saved in:
Bibliographic Details
Published inJournal of pharmaceutical and biomedical analysis Vol. 1; no. 4; p. 507
Main Authors van de Vaart, F J, Hulshoff, A, Indemans, A W
Format Journal Article
LanguageEnglish
Published England 1983
Online AccessGet more information

Cover

More Information
Summary:The analysis without prior sample clean-up of promethazine hydrochloride or clioquinol in commercially available creams has been investigated using UV-spectrophotometry and titrimetric methods. The results were compared with those obtained by GLC and HPLC. Although in some cases the active drug could be determined satisfactorily using the comparatively non-selective UV-absorbance or titrimetric methods, these methods were found to be reliable only when applied to creams for which the qualitative and quantitative composition was completely known. Without prior sample clean-up, these methods will therefore be of interest mainly for process control purposes in manufacturing.
ISSN:0731-7085
DOI:10.1016/0731-7085(83)80064-8