Values of intravenous ergonovine test with two-dimensional echocardiography for diagnosis of coronary artery spasm

• Published in: Journal of the American Society of Echocardiography Vol. 7; no. 6; p. 607
• Main Authors: Song, J K, Park, S W, Kim, J J, Doo, Y C, Kim, W H, Park, S J, Lee, S J
• Format: Journal Article
• Language: English
• Published: United States 01.11.1994
• Subjects: Angina Pectoris, Variant - diagnosis; Angina Pectoris, Variant - diagnostic imaging; Coronary Angiography; Coronary Vasospasm - diagnosis; Coronary Vasospasm - diagnostic imaging; Echocardiography; Electrocardiography; Ergonovine - analogs & derivatives; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Myocardial Contraction - physiology; Sensitivity and Specificity; Ventricular Function, Left - physiology
• ISSN: 0894-7317
• DOI: 10.1016/S0894-7317(14)80083-7

The purpose of this study was to evaluate the clinical validity of the bedside ergonovine test with digital echocardiography and the side-by-side continuous cineloop display method (ergonovine echocardiography) as a noninvasive diagnostic tool for coronary artery spasm. Bedside ergonovine test was performed in 66 patients who showed coronary vasospasm during coronary angiography including provocation testing (group with variant angina) and 39 patients with normal angiograms and no evidence of coronary artery spasm (group with nonanginal pain). A bolus of ergonovine maleate (0.025 or 0.05 mg) was injected at 5-minute intervals up to total cumulative dosage of 0.35 mg, and 12-lead electrocardiography and two-dimensional echocardiography were recorded every 3 minutes after each injection. Left ventricular wall motion was analyzed with a commercially available quad system. The positive criteria of bedside ergonovine test included reversible ST segment elevation or depression on electrocardiograms (ECG criteria) and reversible regional wall motion abnormalities by echocardiography (Echo criteria). The overall sensitivity and specificity of ECG criteria were 53% (35/66; 95% confidence interval 41% to 65%) and 100%, respectively. By Echo criteria the sensitivity increased to 89% (59/66; 95% confidence interval 81% to 97%), with a specificity of 95% (37/39).