Mutations in tumour suppressor gene p53 in two feline fibrosarcomas

Exons 5–7 of the tumour suppressor gene p53 were investigated in genomic DNA of tumours of domestic cats. In one fibrosarcoma investigated we observed a mutation GAG → AAG (glutamic acid → lysine) in codon 180; in another there was a mutation CGG → TGG (arginine → tryptophane) in codon 248....

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Published inBritish veterinary journal Vol. 151; no. 6; pp. 707 - 713
Main Authors Mayr, B., Schaffner, G., Kurzbauer, R., Schneider, A., Reifinger, M., Loupal, G.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.1995
Subjects
Animals
Base Sequence
Cat Diseases - genetics
Cats
Fibrosarcoma - genetics
Fibrosarcoma - veterinary
Genes, p53 - genetics
Male
Molecular Sequence Data
Point Mutation - genetics
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Summary:Exons 5–7 of the tumour suppressor gene p53 were investigated in genomic DNA of tumours of domestic cats. In one fibrosarcoma investigated we observed a mutation GAG → AAG (glutamic acid → lysine) in codon 180; in another there was a mutation CGG → TGG (arginine → tryptophane) in codon 248.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-1935
DOI:10.1016/S0007-1935(95)80151-0