A histologic study of experimental oro-paranasal communications in monkeys

• Published in: International journal of oral surgery Vol. 1; no. 5; pp. 250 - 257
• Main Authors: Haanaes, Hans Reidar, Gilhuus-Moe, Ole
• Format: Journal Article
• Language: English
• Published: Denmark Elsevier Inc 1972
• Subjects: Animals; Dentistry; Epithelium - pathology; Haplorhini; Macaca; Maxillary Sinus; Metaplasia; Molar; monkey; Mucous Membrane - pathology; oro-paranasal communication; Oroantral Fistula; Time Factors; Tooth Extraction; Wound Healing; oro-paranasal communication; monkey
• ISSN: 0300-9785
• DOI: 10.1016/S0300-9785(72)80044-9

Experimental oro-paranasal communications were established in 11 monkeys (Macaca it-its) through the alveoli of the maxillary first or second molars after extraction of one of these teeth. The morphologic changes of the mucous membrane of the maxillary sinus and adjacent tissues following the experimental trauma were studied. Particular attention was focused on the metaplastic changes of the respiratory epithelium of the injured areas. The observation time ranged from 2 d to 12 weeks. Areas of nonreversible epithelial metaplasia to squamous and cuboid-like nonkeratinized epithelium were observed frequently throughout the observation period in the traumatized region. Mesenchymal cell proliferation from the fibrous portion of the maxillary sinus periosteum separated the antrum from the oral cavity completely within 7-14 d following the experimental oro-paranasal communication. Oro-paranasal fistulas did not develop in any of the experimental animals.