Genotype comparison of Candida albicans isolates from different clinical samples

Abstract Background : Fungal infections are a health issue paradoxically fuelled by the developments in medical care. Objectives: Our study is an investigation on the correlation between the infection site and the genotypes of Candida albicans strains isolated from Romanian patients. Methods : A tot...

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Published inRevista română de medicină de laborator Vol. 27; no. 3; pp. 327 - 332
Main Authors Bostănaru, Andra-Cristina, Roșca, Irina, Minea, Bogdan, Năstasă, Valentin, Foia, Liliana, Marincu, Iosif, Mares, Mihai, Mederle, Ovidiu-Alexandru
Format Journal Article
LanguageEnglish
Published Sciendo 01.07.2019
Subjects
c. albicans
clinical source
genotype c
hiv-patients
romania
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Summary:Abstract Background : Fungal infections are a health issue paradoxically fuelled by the developments in medical care. Objectives: Our study is an investigation on the correlation between the infection site and the genotypes of Candida albicans strains isolated from Romanian patients. Methods : A total number of 301 isolates from different clinical sites were investigated in terms of genotype determination. Results : The isolates were clustered in three groups according to their genotype: 55.81% showed genotype A, 14.62% genotype B, and 29.57% genotype C. Conclusions : No significant correlation was found between the genotype and the infection site, but a significant correlation was found between genotype C and isolates from HIV patients proving that C. albicans pathogenicity probably relies on factors related to the host.
ISSN:2284-5623
2284-5623
DOI:10.2478/rrlm-2019-0027