Qi-dan-di-huang decoction alleviates diabetic nephropathy by inhibiting the NF-kappaB pathway

• Published in: Frontiers in bioscience Vol. 24; no. 8; pp. 1477 - 1486
• Main Authors: Ma, Fei, Li, Lingxing, Wang, Qian, Chen, Zujiang, You, Yanting, Gao, Peiping, Zhao, Xiaoshan, Luo, Ren
• Format: Journal Article
• Language: English
• Published: Singapore 01.06.2019
• Subjects: Animals; Cytokines - blood; Diabetes Mellitus, Experimental - complications; Diabetic Nephropathies - complications; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - prevention & control; Drugs, Chinese Herbal - pharmacology; Fibrosis; Glycogen - metabolism; Humans; Inflammation Mediators - blood; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Male; NF-kappa B - metabolism; Rats, Sprague-Dawley; Signal Transduction - drug effects
• ISSN: 1093-9946; 2768-6698; 1093-4715
• DOI: 10.2741/4792

Diabetic nephropathy (DN) is one of the most serious complications of diabetes mellitus, for which no effective treatment currently exists. We tested the hypothesis that Qi-dan-di-huang (QDDH) might have therapuetic effects in an experimental rat model of DN. The levels of I kappa KinaseAlpha and Beta, p-p65, p-IκB alpha, TGF-β1 and Alpha-SMA were significantly increased in kidneys in DN. QDDH decoction only partially reversed the increased Ikappa KinaseAlpha/Beta, p-p65, p-IKappaB alpha, TGF-Beta1 and alpha-SMA in the kidneys in DN. However, treatment of diabetic rats with QDDH decoction significantly inhibited the production and release of inflammatory cytokines IL-6, IL-1 beta and TNF-alpha into the serum. QDDH decoction also significantly improved the physiologic and biochemical indicators of DN, reduced glycogen and protein deposition in DN and prevented renal fibrosis. Together, the data show that QDDH decoction exerts a protective effect on kidneys in diabetic rats and reverses the inflammatory milieu of the serum in DN.