The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity

• Published in: Prostaglandins Vol. 2; no. 6; pp. 519 - 528
• Main Authors: Lichtenstein, L.M., Gillespie, E., Bourne, H.R., Henney, C.S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.1972
• Subjects: Allergens; Animals; Basophils - drug effects; Buffers; Chromium Isotopes; Cyclic AMP - metabolism; Fluorometry; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Immunity, Cellular - drug effects; Immunoglobulin E - biosynthesis; Leukocytes - immunology; Lymphocytes - immunology; Mast Cells - immunology; Mice; Mice, Inbred C57BL - immunology; Pollen; Prostaglandins - pharmacology; Protein Binding; Tritium

We report here on the interaction of prostaglandins with two in vitro models of immunologic responses: the antigen induced, IgE mediated release of histamine from isolated human leukocytes and the cytolysis of DBA/2 mouse mastocytoma cells by sensitized splenic lymphocytes from C57B1 mice. Both reac...