Antiproliferative and Apoptotic Effects of Murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and Taperebá (Spondias mombin L.) Extracts in Human Prostate Cell Line (PC-3)

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 25; no. 4; pp. 1339 - 1347
• Main Authors: Amaral Muxfeldt Paim, Thuane Oliveira Do, Simas, Nayara Frauches, Abreu, Joel Pimentel, Rosa, Lana, Passos Barbosa Lima, Thuane, Teodoro, Anderson Junger
• Format: Journal Article
• Language: English
• Published: Thailand West Asia Organization for Cancer Prevention 01.04.2024
• Subjects: Apoptosis - drug effects; Cell Cycle - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Humans; Male; PC-3 Cells; Plant Extracts - pharmacology; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; Tumor Cells, Cultured; cancer; prostate; Taperebá; Amazon Fruits; Murici
• ISSN: 1513-7368; 2476-762X
• DOI: 10.31557/APJCP.2024.25.4.1339

The present study aimed to evaluate the antiproliferative and apoptotic effects of extracts obtained from the murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and taperebá (Spondias mombin L.) pulps, on cell proliferation, cell cycle and apoptosis on human prostate cell line (PC-3). Four extract was produced from the pulps:  murici aqueous extract (MA), taperebá aqueous extract (TA), murici ethanolic extract (ME) and taperebá ethanolic extract (TE). In the present study, the analysis of cell viability, cell cycle and apoptosis analyze were performed using the MTT method and flow cytometry. The results showed that murici and taperebá extracts proved to be inhibitors of cell growth, modulation of cell cycle promoters and capable of enhancing the death in prostate carcinoma cells PC-3; suggesting a regulatory effect in prostate cell line, depending on type of extract and dosage used. These results open a series of perspectives on the use of these bioactive extracts in the prevention and treatment of prostate cancer.