Function of Cryopreserved Mesenchymal Stromal Cells With and Without Interferon‐γ Prelicensing is Context Dependent

Tailoring MSCs to fit the disease. Fresh, cryopreserved and, prelicensed cryopreserved MSC are all being explored to treat numerous diseases, but all are not suitable to treat all conditions. injury. “*” denotes preferred therapeutic strategy when both fresh MSC and cryo‐MSC have shown utility in tr...

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Published inStem cells (Dayton, Ohio) Vol. 35; no. 5; pp. 1437 - 1439
Main Authors Burand, Anthony J., Gramlich, Oliver W., Brown, Alex J., Ankrum, James A.
Format Journal Article
LanguageEnglish
Published United States 01.05.2017
Subjects
Animals
Cell transplantation
Cryopreservation
Humans
Immunosuppression
Indoleamine 2,3 dioxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism
Interferon-gamma - pharmacology
Mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - drug effects
Mice, Inbred C57BL
Reperfusion Injury - pathology
Retina
Retina
Immunosuppression
Indoleamine 2,3 dioxygenase
Cell transplantation
Mesenchymal stem cells
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Summary:Tailoring MSCs to fit the disease. Fresh, cryopreserved and, prelicensed cryopreserved MSC are all being explored to treat numerous diseases, but all are not suitable to treat all conditions. injury. “*” denotes preferred therapeutic strategy when both fresh MSC and cryo‐MSC have shown utility in treating the disease but one is more efficacious or logistically suitable. Abbreviations: CLI, critical limb ischemia; GvHD. graft versus host disease; I/R, ischemia reperfusion (I/R); OI, osteogenesis imperfecta.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:1066-5099
1549-4918
DOI:10.1002/stem.2528