Analysis of IL-10 in HIV-1 patients with chronic periodontitis in northern Brazil

• Published in: Brazilian journal of oral sciences Vol. 16; pp. 1 - 9
• Main Authors: Menezes, Silvio Augusto Fernandes de, Menezes, Tatiany Oliveira de Alencar, Rodrigues, Tânia Maria de Souza, Nogueira, Brenna Magdalena Lima, Fonseca, Ricardo Roberto de Souza
• Format: Journal Article
• Language: English
• Published: Universidade Estadual de Campinas 2018
• Subjects: Interleukin-10. HIV and Chronic Periodontitis
• DOI: 10.20396/bjos.v16i0.8651054
• ISSN: 1677-3225

Aim: The objective of this study was to investigate the levels of IL-10 in the gingival crevicular fluid in HIV-1 positive patients with chronic periodontitis and to compare with HIV-1 negative patients with chronic periodontitis, also to correlate clinical periodontal parameters, viral load and count of CD4+ and CD8+ lymphocytes (LTCD4+ and LTCD8+). Methods: 33 patients were selected and splitted into two groups: 16 HIV-1 positive patients and 17 HIV-1 negative patients and all with chronic periodontitis. The clinical periodontal parameters recorded were: Probing Depth (PD) and Clinical Attachment Level (CAL); the sistemical parameters LTCD4+, LTCD8+ and viral load were analized by the gingival crevicular fluid collected from all patients. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentrations of Interleukin (IL)-10. For the statistical analysis the Student t, Mann-Whitney and Spearman tests were performed. IL-10 levels were significantly lower in both patients groups. Results: There was statistical difference betwen groups for probing depth (p=0.015) and clinical attachment level (p=0.011), no significant correlation was found among the analyzed variables. Conclusion: The IL-10 levels in HIV-1 positive patients had no influence in periodontal and medical parameters.