Analysis of IL-10 in HIV-1 patients with chronic periodontitis in northern Brazil

Aim: The objective of this study was to investigate the levels of IL-10 in the gingival crevicular fluid in HIV-1 positive patients with chronic periodontitis and to compare with HIV-1 negative patients with chronic periodontitis, also to correlate clinical periodontal parameters, viral load and cou...

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Bibliographic Details
Published inBrazilian journal of oral sciences Vol. 16; pp. 1 - 9
Main Authors Menezes, Silvio Augusto Fernandes de, Menezes, Tatiany Oliveira de Alencar, Rodrigues, Tânia Maria de Souza, Nogueira, Brenna Magdalena Lima, Fonseca, Ricardo Roberto de Souza
Format Journal Article
LanguageEnglish
Published Universidade Estadual de Campinas 2018
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Summary:Aim: The objective of this study was to investigate the levels of IL-10 in the gingival crevicular fluid in HIV-1 positive patients with chronic periodontitis and to compare with HIV-1 negative patients with chronic periodontitis, also to correlate clinical periodontal parameters, viral load and count of CD4+ and CD8+ lymphocytes (LTCD4+ and LTCD8+). Methods: 33 patients were selected and splitted into two groups: 16 HIV-1 positive patients and 17 HIV-1 negative patients and all with chronic periodontitis. The clinical periodontal parameters recorded were: Probing Depth (PD) and Clinical Attachment Level (CAL); the sistemical parameters LTCD4+, LTCD8+ and viral load were analized by the gingival crevicular fluid collected from all patients. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentrations of Interleukin (IL)-10. For the statistical analysis the Student t, Mann-Whitney and Spearman tests were performed. IL-10 levels were significantly lower in both patients groups. Results: There was statistical difference betwen groups for probing depth (p=0.015) and clinical attachment level (p=0.011), no significant correlation was found among the analyzed variables. Conclusion: The IL-10 levels in HIV-1 positive patients had no influence in periodontal and medical parameters.
ISSN:1677-3225
1677-3225
DOI:10.20396/bjos.v16i0.8651054