Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO2 by using sequential administration of 15O-labeled compounds

• Published in: Annals of nuclear medicine Vol. 16; no. 5; pp. 317 - 327
• Main Authors: Shidahara, Miho, Watabe, Hiroshi, Kim, Kyeong Min, Oka, Hisashi, Sago, Masayoshi, Hayashi, Takuya, Miyake, Yoshinori, Ishida, Yoshio, Hayashida, Kohei, Nakamura, Takashi, Iida, Hidehiro
• Format: Journal Article
• Language: English
• Published: Japan Springer Nature B.V 01.07.2002
• Subjects: Adult; Algorithms; Blood Volume Determination - methods; Brain; Brain - blood supply; Brain - diagnostic imaging; Brain - physiology; Cerebrovascular Circulation; Data acquisition; Datasets; Delay time; Evaluation; Humans; Image acquisition; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Image reconstruction; Male; Oxygen - metabolism; Oxygen Consumption; Oxygen Radioisotopes - classification; Positron emission tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Studies; Tomography, Emission-Computed - instrumentation; Tomography, Emission-Computed - methods; Tracers
• ISSN: 0914-7187; 1864-6433
• DOI: 10.1007/bf02988616

The purpose of this study was to develop a reliable and practical strategy that generates quantitative CBF and OEF maps accurately from PET data sets obtained with 15O-tracers. Sequential sinogram data sets were acquired after the administration of 15O-tracers, and combined single-frame images were obtained. The delay time between sampled input function and the brain was estimated from the H2(15)O study with the whole brain and the arterial time-activity curves (TACs). The whole-brain TACs were obtained from the reconstructed images (image-base method) and the sinogram data (sinogram-base method). Six methods were also evaluated for the dead-time and decay correction procedures in the process of generating a single-frame image from the dynamic sinogram. The estimated delay values were similar with both the sinogram-based and image-based methods. A lumped correction factor to a previously added single-frame sinogram caused an underestimation of CBF, OEF and CMRO2 by 16% at maximum, as compared with the correction procedure for a short sinogram. This suggested the need for a dynamic acquisition of a sinogram with a short interval. The proposed strategy provided an accurate quantification of CBF and OEF by PET with 15O-tracers.