Boron Neutron Capture Therapy Study of 10B Enriched Nanostructured Boron Carbide Against Cervical Cancer and Glioblastoma Cell Line

Boron carbide enriched with 10 B isotope ( 10 B 4 C) was synthesized by simple and low cost solvothermal method. Structural, morphological and optical analysis has been done. Hexagonal phase of the synthesized material show emission in visible region and makes it a promising material for cancer diag...

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Bibliographic Details
Published inJournal of cluster science Vol. 32; no. 1; pp. 221 - 225
Main Authors Kaur, Manjot, Singh, Paviter, Meena, Ramovatar, Nakagawa, Fumiko, Suzuki, Minoru, Nakamura, Hiroyuki, Kumar, Akshay
Format Journal Article
LanguageEnglish
Published New York Springer US 2021
Springer Nature B.V
Subjects
Biocompatibility
Biomedical materials
Boron
Boron carbide
Brief Communication
Cancer
Cancer therapies
Catalysis
Cell death
Cervical cancer
Chemistry
Chemistry and Materials Science
Cost analysis
Cytotoxicity
Hexagonal phase
Inorganic Chemistry
Morphology
Nanochemistry
Nanoparticles
Neutrons
Nuclear capture
Oxidative stress
Particle size
Physical Chemistry
Pore size
Synthesis
Thermal neutrons
Transmission electron microscopy
Tumors
X-rays
Cytotoxicity
B
C
Boron neutron capture therapy
Photoluminescence
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Summary:Boron carbide enriched with 10 B isotope ( 10 B 4 C) was synthesized by simple and low cost solvothermal method. Structural, morphological and optical analysis has been done. Hexagonal phase of the synthesized material show emission in visible region and makes it a promising material for cancer diagnosis. Cytotoxicity analysis has been done to analyze its suitability for biomedical applications. Boron neutron capture therapy (BNCT) has been performed using thermal neutron source in comparison to clinically studied compound on tumor cell lines (HeLa and U-87MG).
ISSN:1040-7278
1572-8862
DOI:10.1007/s10876-020-01773-z