Human papillomavirus-related oropharyngeal squamous cell carcinoma: a new context for dysphagia rehabilitation

‘Head and neck squamous cell carcinoma (HNSCC)’ references a collection of malignant lesions located across several sites within the upper aerodigestive tract. Traditionally, the majority of HNSCCs arise within the oral cavity and larynx, resulting from the field cancerization effects of tobacco and...

Full description

Saved in:
Bibliographic Details
Published inCurrent physical medicine and rehabilitation reports Vol. 2; no. 4; pp. 231 - 240
Main Authors Theurer, Julie A., Yoo, John, Nichols, Anthony C.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.12.2014
Springer Nature B.V
Subjects
Alcohol
Cancer therapies
Carcinogens
Chemotherapy
Dysphagia
Human papillomavirus
Infections
Larynx
Medical prognosis
Medicine
Medicine & Public Health
Metastasis
Mutation
Patients
Radiation therapy
Rehabilitation Medicine
Respiration
Risk factors
Section Editor
Squamous cell carcinoma
Surgery
Swallowing
Swallowing Disorders (RE Martin
Throat cancer
Tobacco
Tumors
Oropharyngeal squamous cell carcinoma
Head and neck cancer
Human papillomavirus
Dysphagia
Swallowing
Online AccessGet full text

Cover

More Information
Summary:‘Head and neck squamous cell carcinoma (HNSCC)’ references a collection of malignant lesions located across several sites within the upper aerodigestive tract. Traditionally, the majority of HNSCCs arise within the oral cavity and larynx, resulting from the field cancerization effects of tobacco and alcohol exposure. However, over the last three decades, the incidence of cancers in the oropharynx has risen dramatically. Compelling evidence now links the epidemic of oropharyngeal squamous cell carcinomas (OPSCCs) to human papillomavirus (HPV) infection. This virally mediated disease boasts unique epidemiologic, mechanistic, and clinic-demographic features, of which clinicians and clinician-scientists should be aware, particularly in light of the estimated increasing prevalence of this disease in the foreseeable future. While survival and oncologic outcomes associated with HPV-related OPSCC are very promising, what remains less clear is patient functioning following curative-intent therapeutic regimens designed relative to tobacco- and alcohol-related disease.
ISSN:2167-4833
2167-4833
DOI:10.1007/s40141-014-0058-x