Ligand- and base-free synthesis of 1,3-diynes catalyzed by low loading of heterogeneous Pd/C and cuI

A facile and environmentally friendly synthetic method for a variety of symmetrical 1,3-diyne derivatives based on the Pd/C-Cul-catalyzed homocoupling reaction of terminal alkynes has been developed. The reaction was efficiently catalyzed by the extrernely low loading (0.01-0.03 mol%) of Pd/C and Cu...

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Bibliographic Details
Published inSynlett no. 16; pp. 2521 - 2524
Main Authors Kurita, Takanori, Abe, Masami, Maegawa, Tomohiro, Monguchi, Yasunari, Sajiki, Hironao
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.10.2007
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ROUTE
homocoupling
HOMOCOUPLING REACTION
heterogeneous palladium on carbon
terminal alkynes
ALLYLAMINE DERIVATIVES
FACILE
ligand- and base-free
oxygen
PANAXYTRIOL
DIYNES
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Summary:A facile and environmentally friendly synthetic method for a variety of symmetrical 1,3-diyne derivatives based on the Pd/C-Cul-catalyzed homocoupling reaction of terminal alkynes has been developed. The reaction was efficiently catalyzed by the extrernely low loading (0.01-0.03 mol%) of Pd/C and Cul (3 mol%) in the presence of molecular oxygen (02) as an oxidant without any phosphine ligands and bases.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2007-986663