Practical regioselective bromination of azaindoles and diazaindoles

A mild and efficient synthesis of various 3-brominated azaindoles and diazaindoles was developed by regioselective halogenation of the parent systems. This practical and high-yielding transformation was achieved with copper(II) bromide in acetonitrile at room temperature.

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Bibliographic Details
Published inSynlett no. 2; pp. 211 - 214
Main Authors Gallou, Fabrice, Reeves, Jonathan T., Tan, Zhulin, Song, Jinhua J., Yee, Nathan K., Harcken, Christian, Liu, Pingrong, Thomson, David, Senanayake, Chris H.
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.02.2007
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ROUTE
regioselective halogenation
5-AZAINDOLES
4-AZAINDOLES
VERSATILE
3-brominated azaindoles
EFFICIENT SYNTHESIS
6-AZAINDOLES
INHIBITORS
7-AZAINDOLES
copper(II) bromide
DERIVATIVES
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Summary:A mild and efficient synthesis of various 3-brominated azaindoles and diazaindoles was developed by regioselective halogenation of the parent systems. This practical and high-yielding transformation was achieved with copper(II) bromide in acetonitrile at room temperature.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2007-967998