Condensation of chromone-3-carboxaldehyde with phenylacetic acids: An efficient synthesis of (E)-3-styrylchromones

An efficient and diastereoselective synthetic method for preparing (E)-3-styrylchromones has been developed by the reaction of chromone-3-carboxaldehyde with phenylacetic acids in the presence of potassium tert-butoxide under classical heating conditions or microwave irradiation. The Knoevenagel-typ...

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Bibliographic Details
Published inSynlett no. 15; pp. 2717 - 2720
Main Authors Silva, VLM, Silva, AMS, Pinto, DCGA, Cavaleiro, JAS, Patonay, T
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 07.12.2004
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
phenylacetic acids
(E)-3-styrylchromones
MICROWAVE
chromone-3-carboxaldehyde
condensation
microwave irradiation
POLYHYDROXYLATED 2-STYRYLCHROMONES
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Summary:An efficient and diastereoselective synthetic method for preparing (E)-3-styrylchromones has been developed by the reaction of chromone-3-carboxaldehyde with phenylacetic acids in the presence of potassium tert-butoxide under classical heating conditions or microwave irradiation. The Knoevenagel-type reaction followed by a decarboxylation was faster under microwave conditions.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2004-835660