Mono- and bis-acrolein derivatives by reliable and efficient one-step methylenation of aldehyde precursors

• Published in: Synthesis (Stuttgart) no. 17; pp. 2841 - 2844
• Main Authors: Basu, K, Richards, J, Paquette, LA
• Format: Journal Article
• Language: English
• Published: STUTTGART Thieme Medical Publishers 01.12.2004
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; 1,2-dichloroethane; acroleins; alpha,beta-unsaturated aldehydes; one-step reaction; diethylamine hydrochloride

A series of aldehydes carrying different functional groups was transformed directly into the a-methylene derivatives. Dialdehydes behaved comparably at both active sites. When keto aldehydes are involved, excellent levels of chemoselectivity are observed, with the ketone substructures exhibiting no...