Mono- and bis-acrolein derivatives by reliable and efficient one-step methylenation of aldehyde precursors

A series of aldehydes carrying different functional groups was transformed directly into the a-methylene derivatives. Dialdehydes behaved comparably at both active sites. When keto aldehydes are involved, excellent levels of chemoselectivity are observed, with the ketone substructures exhibiting no...

Full description

Saved in:
Bibliographic Details
Published inSynthesis (Stuttgart) no. 17; pp. 2841 - 2844
Main Authors Basu, K, Richards, J, Paquette, LA
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.12.2004
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
1,2-dichloroethane
acroleins
alpha,beta-unsaturated aldehydes
one-step reaction
diethylamine hydrochloride
Online AccessGet more information

Cover

More Information
Summary:A series of aldehydes carrying different functional groups was transformed directly into the a-methylene derivatives. Dialdehydes behaved comparably at both active sites. When keto aldehydes are involved, excellent levels of chemoselectivity are observed, with the ketone substructures exhibiting no sign of reactivity.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2004-834866