Suzuki coupling at the 2-position of densely functionalized pyrimidones

A variety of ethyl 1-substituted2-aryl-5-ethoxy-6-oxo-1,6-dihydropyrimidine-4-carboxylates were synthesized by efficient thermal or microwave-promoted Suzuki coupling of 2-chloro-N1-substituted precursors.

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Published inSynthesis (Stuttgart) no. 8; pp. 1343 - 1350
Main Authors Colarusso, S, Girardin, M, Conte, Narjes, F
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 19.04.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
antiviral agents
ACIDS
pyrimidones
cross-coupling
POLYMERASE
CONVENIENT
ARYL
INHIBITORS
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Abstract A variety of ethyl 1-substituted2-aryl-5-ethoxy-6-oxo-1,6-dihydropyrimidine-4-carboxylates were synthesized by efficient thermal or microwave-promoted Suzuki coupling of 2-chloro-N1-substituted precursors.
AbstractList A variety of ethyl 1-substituted2-aryl-5-ethoxy-6-oxo-1,6-dihydropyrimidine-4-carboxylates were synthesized by efficient thermal or microwave-promoted Suzuki coupling of 2-chloro-N1-substituted precursors.
Author Colarusso, S
Narjes, F
Girardin, M
Conte
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10.1021/ol016971g
10.1021/jm0494669
10.1002/anie.200400655
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Keywords antiviral agents
ACIDS
pyrimidones
cross-coupling
POLYMERASE
CONVENIENT
ARYL
INHIBITORS
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Snippet A variety of ethyl 1-substituted2-aryl-5-ethoxy-6-oxo-1,6-dihydropyrimidine-4-carboxylates were synthesized by efficient thermal or microwave-promoted Suzuki...
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SubjectTerms Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Title Suzuki coupling at the 2-position of densely functionalized pyrimidones
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