Suzuki coupling at the 2-position of densely functionalized pyrimidones

A variety of ethyl 1-substituted2-aryl-5-ethoxy-6-oxo-1,6-dihydropyrimidine-4-carboxylates were synthesized by efficient thermal or microwave-promoted Suzuki coupling of 2-chloro-N1-substituted precursors.

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 8; pp. 1343 - 1350
Main Authors Colarusso, S, Girardin, M, Conte, Narjes, F
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 19.04.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
antiviral agents
ACIDS
pyrimidones
cross-coupling
POLYMERASE
CONVENIENT
ARYL
INHIBITORS
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Summary:A variety of ethyl 1-substituted2-aryl-5-ethoxy-6-oxo-1,6-dihydropyrimidine-4-carboxylates were synthesized by efficient thermal or microwave-promoted Suzuki coupling of 2-chloro-N1-substituted precursors.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2006-926414