A simple protocol for the generation of methyl(trifluoromethyl)dioxirane

Methyl(trifluoromethyl)dioxirane, generated from an aqueous solution of 1,1,1-trifluoroacetone hydrate, sodium bicarbonate and peroxomonosulfate, is removed from the reaction mixture by the evolved gases and applied to the oxidation of substrates placed in a second reaction zone. The method is simpl...

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Bibliographic Details
Published inSynlett no. 1; pp. 47 - 50
Main Authors Mello, Rossella, Gonzalez-Nunez, Maria Elena, Asensio, Gregorio
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 04.01.2007
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
synthesis
SELECTIVE OXIDATION
dioxiranes
CONVERSION
oxidation
DECOMPOSITION
oxygenation
C-H BONDS
EPOXIDATION
NONNATURAL TARGETS
methyl(trifluoromethyl)dioxirane
NATURAL TARGETS
CHEMISTRY
OXYFUNCTIONALIZATION
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Summary:Methyl(trifluoromethyl)dioxirane, generated from an aqueous solution of 1,1,1-trifluoroacetone hydrate, sodium bicarbonate and peroxomonosulfate, is removed from the reaction mixture by the evolved gases and applied to the oxidation of substrates placed in a second reaction zone. The method is simple and robust, and allows for the application of methyl(trifluoromethyl)dioxirane in oxidation reactions on a preparative scale.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-958422