Novel approach towards the synthesis of 3,3a,4,5-tetrahydroquinolino-[4,3-c]isoxazole derivatives: Application to the preparation of previously unattainable 3a,4-dihydroazabenzopyrano[4,3-c]isoxazole scaffolds

A novel synthetic approach towards the preparation of 3-substituted-7,8-dimethoxy-3,3a,4,5-tetrahydroquinolino[4,3-c]isoxazole derivatives is reported. Further application of this methodology to the preparation of previously unattainable 3a,4-dihydroazabenzopyrano[4,3-c]isoxazole derivatives is also...

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Bibliographic Details
Published inSynlett no. 20; pp. 3139 - 3141
Main Authors Alcazar, J, Alonso, JM, Andres, JI, Bartolome, JM, Fernandez, J
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 19.12.2005
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
isoxazolines
ALPHA-ADRENOCEPTOR ANTAGONISTIC ACTIVITIES
fused-ring systems
SERIES
heterocycles
ring closure
antidepressants
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Summary:A novel synthetic approach towards the preparation of 3-substituted-7,8-dimethoxy-3,3a,4,5-tetrahydroquinolino[4,3-c]isoxazole derivatives is reported. Further application of this methodology to the preparation of previously unattainable 3a,4-dihydroazabenzopyrano[4,3-c]isoxazole derivatives is also described.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-921909