Lactiplantibacillus plantarum CCFM8661 alleviates D-galactose-induced brain aging in mice by the regulation of the gut microbiota

• Published in: Food & function Vol. 14; no. 22; pp. 10135 - 10150
• Main Authors: Chen, Feng, Pan, Jiani, Yu, Leilei, Wang, Shunhe, Zhang, Chengcheng, Zhao, Jianxin, Narbad, Arjan, Zhai, Qixiao, Tian, Fengwei
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 13.11.2023
• Subjects: Aging; Aging (artificial); Animals; Brain; Brain damage; Cognitive ability; D-Galactose; Digestive system; Galactose; Galactose - adverse effects; Gastrointestinal Microbiome; Gastrointestinal tract; Intestinal microflora; Lactiplantibacillus plantarum; Metabolites; Mice; Microbiota; Microorganisms; Oral administration; Oxidation; Oxidative Stress
• ISSN: 2042-6496; 2042-650X
• DOI: 10.1039/d3fo03377e

Aging is characterized by a decline in biological functions, leading to various health issues. There is significant interest in mitigating age and age-related health issues. Gut microbiota has emerged as a crucial target for combating aging and influencing host health. This study evaluated the anti-aging effects of CCFM8661 in mice and the role of the gut microbiota in mediating its effects. Aging was induced in mice using D-galactose, and CCFM8661 was orally administered for 8 weeks to evaluate its effects on age-related decline and the gut microbiota. The results demonstrated that supplementation with CCFM8661 effectively alleviated cognitive impairment and oxidative stress in the aging brain, as well as liver oxidation and bone damage, and impaired intestinal barrier function in aging mice. Furthermore, CCFM8661 modulated the gut microbiota of aging mice, increasing the abundance of beneficial bacteria, such as Ruminococcaceae, and influenced the functionality of the gut microbiota to promote the production of active metabolites. These findings suggest that CCFM8661 has a mitigating effect on organismal aging, especially brain aging.