Clinical trial of a noninvasive contact lens glucose sensor

The purpose of the present study was to determine the effectiveness of a fluorescent contact lens glucose sensor in monitoring glucose in patients with diabetes. Under an institutional review board-approved protocol, five fasting patients with type II diabetes were given a challenge consisting of 75...

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Bibliographic Details
Published inDiabetes technology & therapeutics Vol. 6; no. 6; p. 782
Main Authors March, Wayne F, Mueller, Achim, Herbrechtsmeier, Peter
Format Journal Article
LanguageEnglish
Published United States 01.12.2004
Subjects
Biosensing Techniques
Blood Glucose - analysis
Blood Glucose Self-Monitoring - instrumentation
Blood Glucose Self-Monitoring - methods
Contact Lenses
Fluorescence
Glucose - analysis
Humans
Monitoring, Physiologic - instrumentation
Monitoring, Physiologic - methods
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Summary:The purpose of the present study was to determine the effectiveness of a fluorescent contact lens glucose sensor in monitoring glucose in patients with diabetes. Under an institutional review board-approved protocol, five fasting patients with type II diabetes were given a challenge consisting of 75 mL of Sustacal (Thomson Micromedex, Greenwood, CO) by mouth. Contact lens fluorescence and venous blood glucose were measured over a 3-h period. Contact lens fluorescence appeared to track blood glucose well. The fluorescent daily-wear disposable contact lenses were comfortable and were tolerated well, even in patients who had not previously worn contact lenses. The contact lens glucose sensor shows promise as a home glucose monitor.
ISSN:1520-9156
DOI:10.1089/dia.2004.6.782