The rhodium carbenoid route to 3-aryl-4-hydroxycoumarins: Synthesis of derrusnin

3-Aryl-4-hydroxycoumarins have been obtained in satisfactory yields and selectivity through a Rh(II)-mediated arylation of diazocoumarin. The utility of this approach is demonstrated by synthesis of the natural product derrusnin.

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Bibliographic Details
Published inSynlett no. 6; pp. 927 - 930
Main Authors Goldoni, L, Cravotto, G, Penoni, A, Tollari, S, Palmisano, G
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 06.04.2005
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
arylations
heterocycles
arene
3-PHENYL-4-HYDROXYCOUMARINS
CHEMISTRY
diazo compounds
DERIVATIVES
TRANSFORMATIONS
rhodium
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Summary:3-Aryl-4-hydroxycoumarins have been obtained in satisfactory yields and selectivity through a Rh(II)-mediated arylation of diazocoumarin. The utility of this approach is demonstrated by synthesis of the natural product derrusnin.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2005-864808