Racial disparity in survival among patients with advanced/recurrent endometrial adenocarcinoma : A gynecologic oncology group study

• Published in: Cancer Vol. 107; no. 9; pp. 2197 - 2205
• Main Authors: MAXWELL, G. Larry, CHUNQIAO TIAN, RISINGER, John, BROWN, Carol L, ROSE, G. Scott, TATE THIGPEN, J, FLEMING, Gini F, GALLION, Holly H, BREWSTER, Wendy R
• Format: Journal Article
• Language: English
• Published: New York, NY Wiley-Liss 01.11.2006
• Subjects: Adenocarcinoma - ethnology; Adenocarcinoma - mortality; Adenocarcinoma - therapy; African Americans - statistics & numerical data; Antineoplastic Combined Chemotherapy Protocols; Biological and medical sciences; Endometrial Neoplasms - ethnology; Endometrial Neoplasms - mortality; Endometrial Neoplasms - therapy; European Continental Ancestry Group - statistics & numerical data; Female; Female genital diseases; Follow-Up Studies; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Neoplasm Recurrence, Local - ethnology; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - therapy; Neoplasm Staging; Randomized Controlled Trials as Topic; Survival Analysis; Tumors; Human; Endometrium cancer; Relapse; Malignant tumor; Survival; Female genital diseases; Cancerology; Race; Uterine diseases; endometrial cancer; Advanced stage; racial disparity; Disparity; Endometrial adenocarcinoma
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/cncr.22232

Previous studies have reported shorter survival of black women compared with white women who had advanced/recurrent endometrial cancer. It has been suggested that this may reflect racially based differences in treatment. The authors retrospectively reviewed data from 169 black women and 982 white women with International Federation of Gynecologic Oncology (FIGO) Stage III, Stage IV, or recurrent endometrial carcinoma who were participants in 1 of 4 Gynecologic Oncology Group randomized treatment trials of doxorubicin alone or combined with paclitaxel and/or cisplatin. Demographic, histologic, treatment, and outcome data were analyzed to estimate survival, and between-group comparisons were performed. The pooled data revealed that black women were more likely to have papillary serous histology (P < .001), Stage IV disease (P < .001), and higher tumor grade (P < .001) compared with white women, and survival was worse among black women than among white women (median survival, 10.6 months vs. 12.2 months, respectively; P < .001). A Cox proportional hazards regression analysis that was adjusted for performance status, disease stage, tumor histology, tumor grade, and treatment demonstrated worse survival for black women (hazards ratio, 1.26, 95% confidence interval, 1.06-1.51; P = .010). The data from a large group of women with advanced/recurrent endometrial cancer suggested that a racial disparity in survival persists, despite the finding that black women and white women received similar treatment. Although the causes of racial disparity in endometrial cancer remain to be elucidated, socioeconomic, biologic, and cultural factors should be investigated to identify the etiologic origins of this multifactorial healthcare problem.