A novel isocyanide-based multicomponent reaction: An easy access to substituted propionamides and succinimides

A new approach to the design of multicomponent reactions is introduced. As a result the novel reaction of gem-diactivated olefins with 4-nitrophenol and isocyanides leading to Substituted propionamides Or succinimides was discovered.

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Bibliographic Details
Published inSynlett no. 4; pp. 615 - 617
Main Authors Mironov, MA, Ivantsova, MN, Mokrushin, VS
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 02.03.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
reaction design
multicomponent reactions
isocyanides
nucleophilic additives
combinatorial chemistry
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Summary:A new approach to the design of multicomponent reactions is introduced. As a result the novel reaction of gem-diactivated olefins with 4-nitrophenol and isocyanides leading to Substituted propionamides Or succinimides was discovered.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2006-933104