Indium(III) chloride/2-iodoxybenzoic acid: A novel reagent system for the conversion of indoles into isatins

Indoles and azaindoles undergo smooth oxidation with 2-iodoxybenzoic acid (IBX) in the presence of indiurn(III) chloride at 80 degrees C to afford the corresponding isatins in excellent yields. This method is very useful for the direct preparation of isatins from indoles. The reaction proceeds smoot...

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 5; pp. 693 - 696
Main Authors Yadav, J. S., Reddy, B. V. Subba, Reddy, Ch. Suresh, Krishna, A. D.
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.03.2007
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
hypervalent iodine
ORGANIC-SYNTHESIS
indole
CATALYZED-REACTIONS
SYNTHETIC APPLICATIONS
IODINE COMPOUNDS
INCL3
indium(III) reagents
isatin
IBX
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Summary:Indoles and azaindoles undergo smooth oxidation with 2-iodoxybenzoic acid (IBX) in the presence of indiurn(III) chloride at 80 degrees C to afford the corresponding isatins in excellent yields. This method is very useful for the direct preparation of isatins from indoles. The reaction proceeds smoothly in aqueous media and the products are obtained in excellent yields.
ISSN:0039-7881
DOI:10.1055/s-2007-965930