Microwave-assisted addition of pyrroles to electron-deficient olefins: A rapid entry to C-alkyl pyrroles

A general procedure for the Michael addition of pyrroles with electron-deficient olefins Using silica gel supported reagent under microwave irradiation, has been developed. This new method is fast, efficient, environmentally benign and solvent-free. A catalytic amount of BiCl3 is employed For modera...

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Bibliographic Details
Published inSynlett no. 16; pp. 2425 - 2428
Main Authors Zhan, ZP, Yang, WZ, Yang, RF
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 04.10.2005
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
MONOTERPENOID INDOLE ALKALOIDS
REAGENT
HALIDES
CATALYSIS
pyrroles
electron-deficient olefins
IRRADIATION
SOLVENT-FREE
CHEMISTRY
microwave irradiation
RECENT PROGRESS
bismuth trichloride
DERIVATIVES
Michael reaction
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Summary:A general procedure for the Michael addition of pyrroles with electron-deficient olefins Using silica gel supported reagent under microwave irradiation, has been developed. This new method is fast, efficient, environmentally benign and solvent-free. A catalytic amount of BiCl3 is employed For moderately bulk electron-deficient olefins.
ISSN:0936-5214
DOI:10.1055/s-2005-872688