Cerebral amyloid angiopathy: diagnosis by MRI and brain biopsy

We report the case of an intellectually deteriorating 66-year-old man who presented with an epileptic seizure. CT of the brain suggested a low-grade astrocytoma, but MRI showed multiple punctate hemorrhagic lesions and a demyelination of vascular origin. Brain biopsy revealed depositions of amyloid...

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Bibliographic Details
Published inNeurology Vol. 40; no. 8; p. 1308
Main Authors Hendricks, H T, Franke, C L, Theunissen, P H
Format Journal Article
LanguageEnglish
Published United States 01.08.1990
Subjects
Aged
Amyloidosis - diagnosis
Amyloidosis - diagnostic imaging
Amyloidosis - pathology
Biopsy
Brain - diagnostic imaging
Brain - pathology
Humans
Magnetic Resonance Imaging
Male
Tomography, X-Ray Computed
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Summary:We report the case of an intellectually deteriorating 66-year-old man who presented with an epileptic seizure. CT of the brain suggested a low-grade astrocytoma, but MRI showed multiple punctate hemorrhagic lesions and a demyelination of vascular origin. Brain biopsy revealed depositions of amyloid in cortical and meningeal arteries. MRI may be of value in diagnosing cerebral amyloid angiopathy associated with leukoencephalopathy and petechial hemorrhages.
ISSN:0028-3878
DOI:10.1212/WNL.40.8.1308