Primary manifestation of HIV-related Burkitt lymphoma in the oral and maxillofacial regions

Burkitt lymphoma (BL) is a subtype of non-Hodgkin lymphoma. It is strongly associated with HIV infection and has a highly aggressive clinical course. The involvement of the maxillofacial region in BL has rarely been reported. A 36-year-old woman with HIV-positive status had painless bilateral swelli...

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Published inThe Journal of the American Dental Association (1939) Vol. 155; no. 4; pp. 344 - 348
Main Authors Silva Filho, Nilton José da, Cardoso, Diovana de Melo, Kayahara, Giseli Mitsuy, Xavier-Júnior, José Cândido Caldeira, Cortopassi, Gabriel Macedo, Fonseca, Felipe Paiva, Miyahara, Glauco Issamu, Bernabé, Daniel Galera, Valente, Vitor Bonetti
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.04.2024
Subjects
Adult
Burkitt lymphoma
Burkitt Lymphoma - complications
Burkitt Lymphoma - diagnosis
Burkitt Lymphoma - pathology
Epstein-Barr Virus Infections - diagnosis
Epstein-Barr Virus Infections - pathology
Female
Herpesvirus 4, Human
HIV infection
HIV Infections - complications
HIV Infections - diagnosis
Humans
oral and maxillofacial regions
primary manifestation
CD
oral and maxillofacial regions
DLBCL
R
NHL
TdT
Burkitt lymphoma
EBV
primary manifestation
Bcl
BL
HIV infection
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Summary:Burkitt lymphoma (BL) is a subtype of non-Hodgkin lymphoma. It is strongly associated with HIV infection and has a highly aggressive clinical course. The involvement of the maxillofacial region in BL has rarely been reported. A 36-year-old woman with HIV-positive status had painless bilateral swelling of the oral mucosa and middle and lower thirds of the face. Microscopic analysis of the oral lesion revealed an atypical lymphoid infiltrate with a starry sky pattern. The lymphoid cells expressed cluster of differentiation 20, cluster of differentiation 10, B-cell lymphoma 6, and c-Myc; the Ki-67 proliferative index was high. The tumor cells were positive for Epstein-Barr virus. These results led to the diagnosis of HIV-related BL. BL and other immunodeficiency-related lymphoproliferative malignancies may affect the oral and maxillofacial regions and should be included in the differential diagnosis of rapidly expanding swelling in young patients.
ISSN:0002-8177
1943-4723
DOI:10.1016/j.adaj.2023.11.012