Declining prevalence of opportunistic gastrointestinal disease in the era of combination antiretroviral therapy
OBJECTIVE:Opportunistic disorders (OD) are the most frequent GI manifestations of the acquired immunodeficiency syndrome (AIDS). Since the introduction of highly active antiretroviral therapy (HAART), there appears to be have been a reduction in the incidence of many of these OD; however, the effect...
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Published in | The American journal of gastroenterology Vol. 95; no. 2; pp. 457 - 462 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
01.02.2000
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Subjects | |
Online Access | Get full text |
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Summary: | OBJECTIVE:Opportunistic disorders (OD) are the most frequent GI manifestations of the acquired immunodeficiency syndrome (AIDS). Since the introduction of highly active antiretroviral therapy (HAART), there appears to be have been a reduction in the incidence of many of these OD; however, the effect of HAART on the prevalence of GI OD has not been well studied.METHODS:From 4/95 through 3/98, all HIV (HIV)-infected patients undergoing GI endoscopy were prospectively identified; mucosal biopsies were obtained in a standardized fashion and histological specimens were examined by a single GI pathologist. Patients were divided into three groups based on the time of evaluation: group I: 4/95 to 3/96; group II: 4/96 to 3/97; and group III: 4/97 to 3/98.RESULTS:A total of 166 patients (90% men; mean age 36 ± 10 yr; median CD4 lymphocyte count 62 cells/μl, range 2-884, median viral RNA level 1,357 copies/ml, range undetectable to 7,721,715) underwent 279 upper and/or lower endoscopies during the study period. There were no statistical differences in patients' demographics and indications for endoscopy although the CD 4 lymphocyte count was higher in group III. The percentage of patients receiving HAART at the time of endoscopy increased from 0% to 57% over the three periods (p < 0.01), and the percentage of patient receiving combination antiretroviral therapy increased from 37% to 82% over the study period (p < 0.01). In contrast, the prevalence of OD decreased from 69% (group I) to 13% (group III) (p < 0.01), whereas the prevalence of non-OD, including a normal endoscopy increased from 31% to 87% (p < 0.01).CONCLUSIONS:GI OD now seem to be an uncommon problem in HIV-infected patients undergoing endoscopy despite a low CD4 lymphocyte count, and this reduction of OD was associated with the use of HAART. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0002-9270 1572-0241 |
DOI: | 10.1111/j.1572-0241.2000.01768.x |