Compatibility of cyclosporine with fat emulsion

The compatibility of cyclosporine with fat emulsion was studied. Admixtures consisted of cyclosporine injection at final drug concentrations of 0.5 and 2.0 mg/mL in 10% and 20% fat emulsion. Fat emulsion stability was determined by visual inspection, pH testing, and particle-size measurements at 0,...

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Bibliographic Details
Published inAmerican journal of hospital pharmacy Vol. 50; no. 4; p. 687
Main Authors Jacobson, P A, Maksym, C J, Landvay, A, Weiner, N, Whitmore, R
Format Journal Article
LanguageEnglish
Published United States 01.04.1993
Subjects
Cyclosporine - chemistry
Drug Incompatibility
Drug Stability
Fat Emulsions, Intravenous - chemistry
Particle Size
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Summary:The compatibility of cyclosporine with fat emulsion was studied. Admixtures consisted of cyclosporine injection at final drug concentrations of 0.5 and 2.0 mg/mL in 10% and 20% fat emulsion. Fat emulsion stability was determined by visual inspection, pH testing, and particle-size measurements at 0, 24, and 48 hours. Cyclosporine stability was measured with high-performance liquid chromatography at the same intervals. The admixtures were stored in glass containers at 23-25 degrees C under fluorescent light. Mean particle diameters remained relatively constant in all the admixtures throughout the study period. No particles larger than 6 microns were observed. Cyclosporine retained more than 96% of its initial concentration in all the admixtures. There were no changes in color or consistency, and pH did not vary by more than 0.11 pH unit. Cyclosporine 0.5 or 2 mg/mL was compatible with 10% or 20% fat emulsion at room temperature in glass containers for up to 48 hours.
ISSN:0002-9289
DOI:10.1093/ajhp/50.4.687