Correlation between hepatic venous pressure gradient and portal pressure gradient in patients with autoimmune cirrhotic portal hypertension and collateral branches of the hepatic vein

• Published in: Hepatology research Vol. 53; no. 11; pp. 1084 - 1095
• Main Authors: Liu, Bowen, Zhang, Dan, Dong, Chengbin, Yue, Zhendong, Wang, Lei, Fan, Zhenhua, Wu, Yifan, Zhang, Ke, Jiang, Li, Ding, Huiguo, Zhang, Yuening, Wang, Jian, Liu, Fuquan
• Format: Journal Article
• Language: English
• Published: Netherlands Wiley Subscription Services, Inc 01.11.2023
• Subjects: Correlation analysis; Hepatic vein; Hypertension; Liver diseases; Veins & arteries; hepatic venous pressure gradient; wedged hepatic venous pressure; autoimmune liver disease; portal hypertension; portal pressure gradient; portal venous pressure
• ISSN: 1386-6346; 1872-034X
• DOI: 10.1111/hepr.13939

To assess the correlation and agreement between hepatic venous pressure gradient (HVPG) and portal pressure gradient (PPG) in patients with autoimmune liver diseases (ALD) and portal hypertension, and to investigate the extent to which hepatic vein collateralization affects the accuracy of this assessment. Ninety-eight patients with ALD between 2017 and 2021 who underwent transjugular intrahepatic portosystemic shunt with conventional and innovative 15 mL pressurized contrast were selected to measure wedged hepatic venous pressure (WHVP) and portal venous pressure and to calculate the HVPG and PPG. Pearson's correlation was used for correlation analysis between the two groups. Bland-Altman plots were plotted to estimate the agreement between paired pressures. The r values of PPG and HVPG in the early, middle, late, and portal venous visualization were 0.404, 0.789, 0.807, and 0.830, respectively, and the R values were 0.163, 0.622, 0.651, and 0.690, respectively. The p value for the r and R values in the early group was 0.015, and the p values in the remaining groups were less than 0.001. Bland-Altman plots showed that patients in the portal venous visualization group had the narrowest 95% limits of agreement. The mean value of the difference was close to the zero-scale line. In patients with ALD, the correlation between the HVPG and PPG was good, and the later the collateral development, the better the correlation. Hepatic vein collateral was an essential factor in underestimating WHVP and HVPG, and the earlier the collateral appeared, the more obvious the underestimation.