Synthesis of a novel lipophilic gadolinium complex as a potential MRI contrast agent

The synthesis of a novel lipophilic diethylentriamino-tetracetic(DTTA)-dodecane gadolinium complex is reported. The Gd-DTTA-dodecane complex is able to form mixed micelles with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPQ and a nonionic surfactant like Tween 80. This novel multicomponent system...

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Bibliographic Details
Published inSynlett no. 17; pp. 2815 - 2817
Main Authors Masotti, Andrea, Remollino, Laura, Carafa, Maria, Marianecci, Carlotta, Santucci, Eleonora, Ortaggi, Giancarlo
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 17.10.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DIAGNOSTIC-TOOLS
DTPA
magnetic resonance imaging
DESIGN
IN-VITRO EVALUATION
gadolinium complex
mixed micelles
magnetic resonance angiography
LIPOSOMES
contrast agent
METAL-COMPLEXES
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Summary:The synthesis of a novel lipophilic diethylentriamino-tetracetic(DTTA)-dodecane gadolinium complex is reported. The Gd-DTTA-dodecane complex is able to form mixed micelles with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPQ and a nonionic surfactant like Tween 80. This novel multicomponent system can find potential application in magnetic resonance angiography (MP,A).
ISSN:0936-5214
DOI:10.1055/s-2006-950281