Possibility of Application of Extracellular Protease of the Micromycetе Aspergillus ochraceus VKM F-4104D for Determination of the Protein C Content in Human Blood Plasma

The protein C activator activity, determined in normal plasma by using A. ochraceus protease is comparable with the activity of a commercial protease analogue from the South American copperhead venom (Protac®). As in the case of Protac®, the A. ochraceus protease can be used for protein C determinat...

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Published inBiochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 12; no. 2; pp. 164 - 166
Main Authors Osmolovskiy, A. A., Orekhova, A. V., Kreyer, V. G., Baranova, N. A., Egorov, N. S.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.04.2018
Springer Nature B.V
Subjects
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Medicinal Chemistry
Protein C
Proteinase
Proteins
Venom
diagnosis of protein C
activators of protein C
proteases of micromycetes
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Summary:The protein C activator activity, determined in normal plasma by using A. ochraceus protease is comparable with the activity of a commercial protease analogue from the South American copperhead venom (Protac®). As in the case of Protac®, the A. ochraceus protease can be used for protein C determination in plasma with its reduced content. Comparison of the activator protein C activity of A. ochraceus protease and the commercial analogue showed some excess of the activator activity of the fungal preparation, which may be a promising substitute for the snake activator in diagnostical kits for determining the protein C content in clinical laboratories.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750818020099