Large scale production of 64Cu and 67Cu via the 64Zn(n, p)64Cu and 68Zn(n, np/d)67Cu reactions using accelerator neutrons

Both 64 Cu and 67 Cu are promising radionuclides in nuclear medicine. Production yields of these radionuclides were quantified by irradiating 55.4 g of natural zinc with accelerator neutrons. Clinically suitable 64 Cu and 67 Cu yields were estimated by experimental based numerical simulations using...

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Published inJournal of radioanalytical and nuclear chemistry Vol. 330; no. 3; pp. 913 - 922
Main Authors Kawabata, Masako, Motoishi, Shoji, Ohta, Akio, Motomura, Arata, Saeki, Hideya, Tsukada, Kazuaki, Hashimoto, Shintaro, Iwamoto, Nobuyuki, Nagai, Yasuki, Hashimoto, Kazuyuki
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 2021
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Deuterons
Diagnostic Radiology
Hadrons
Heavy Ions
Inorganic Chemistry
Neutron flux
Neutrons
Nuclear Chemistry
Nuclear medicine
Nuclear Physics
Physical Chemistry
Radioisotopes
Separation
Zinc
Cu production
Cu
Accelerator neutron
Copper radionuclide separation
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Summary:Both 64 Cu and 67 Cu are promising radionuclides in nuclear medicine. Production yields of these radionuclides were quantified by irradiating 55.4 g of natural zinc with accelerator neutrons. Clinically suitable 64 Cu and 67 Cu yields were estimated by experimental based numerical simulations using 100 g of enriched 64 Zn and 68 Zn, respectively, and elevated neutron fluxes from 40 MeV, 2 mA deuterons. A combined thermal- and resin-separation method was developed to isolate 64 Cu and 67 Cu from zinc, resulting in 73% separation efficiency and 97% zinc recovery. Such methods can provide large scale production of 64 Cu and 67 Cu for clinical applications.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-021-07987-3