Correlation CD24 and CD44 expression against aggressiveness breast cancer

• Published in: Journal of physics. Conference series Vol. 1246; no. 1; pp. 12012 - 12017
• Main Authors: Farida, Aida, Wresnindyatsih, Yuliantini, Venni
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.07.2019
• Subjects: Breast cancer; Chi-square test; Correlation; Glycoproteins; Random sampling; Statistical tests; Stem cells
• ISSN: 1742-6588; 1742-6596
• DOI: 10.1088/1742-6596/1246/1/012012

Cancer stem cells (CSC) in breast cancer are the source of cells that are resistant to chemotherapeutic agents that are responsible for recurrence and metastasis. The existence of CSC is a benchmark for success in strategies for prevention and treatment of breast cancer. Cell surface markers known as cluster of differentiation (CD) 24 are expressed in breast cancer. CD44 is a cell surface protein composed of glycoproteins, high enough to be expressed in breast cancer. Sample taken with technique proportional random sampling. The population of this study is a specimen that has been diagnosed molecular subtype as a breast cancer from January 2015 arrived October 2017, consist of 44 sample, 11 luminal A samples, 11 luminal B samples, 11 HER2 samples and 11 triple negative samples. CD24 expression was found most negative (81.8%) and CD44 expression found the most positive at 84.1%. Expression CD24 correlation with molecular subtype found that the results of the chi-square test found a correlation between expression CD24 and molecular subtype (p-value = 0.036). There correlation expression CD24 molecular subtype but there were no correlation CD24 with limfovaskular invasion, grading, and Ki67. There no correlation expression CD44 with limfovaskular invasion, grading, molecular subtype and Ki67.