A prospective natural history study of inclusion body myositis: implications for clinical trials

Eleven patients with untreated inclusion body myositis (IBM) were prospectively studied during a 6-month period that included muscle strength, lean body mass, and muscle mass measurements. There was an overall quantifiable mean decline in percent of predicted normal muscle strength of 4% from baseli...

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Bibliographic Details
Published inNeurology Vol. 57; no. 3; p. 548
Main Authors Rose, M R, McDermott, M P, Thornton, C A, Palenski, C, Martens, W B, Griggs, R C
Format Journal Article
LanguageEnglish
Published United States 14.08.2001
Subjects
Aged
Clinical Trials as Topic
Disease Progression
Female
Humans
Male
Middle Aged
Myositis, Inclusion Body - physiopathology
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Summary:Eleven patients with untreated inclusion body myositis (IBM) were prospectively studied during a 6-month period that included muscle strength, lean body mass, and muscle mass measurements. There was an overall quantifiable mean decline in percent of predicted normal muscle strength of 4% from baseline in a 6-month period, but one third of patients showed no change or slight improvements in strength. Short-term treatment trials in IBM will require large numbers of patients to detect slowing, arrest, or even slight improvement in muscle strength.
ISSN:0028-3878
DOI:10.1212/WNL.57.3.548